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Hydrogen Peroxide and Hypochlorite Responsive Fluorescent Nanoprobes for Sensitive Cancer Cell Imaging.
- Source :
- Biosensors (2079-6374); Feb2022, Vol. 12 Issue 2, p111, 1p
- Publication Year :
- 2022
-
Abstract
- Accurate diagnosis of cancer cells directly affects the clinical treatment of cancer and can significantly improve the therapeutic effect of cancer patients. Cancer cells have a unique microenvironment with a large amount of peroxide inside, effectively differentiated from relevant microenvironment normal cells. Therefore, designing the high-sensitive probes to recognize and distinguish the special physiological microenvironment of cancer cells can shed light on the early diagnosis of cancers. In this article, we design and construct a fluorescence (FL) contrast agent for cancer cell recognition and imaging analysis. Firstly, luminol-gold NPs (Lum-AuNPs) have been initially built, and then successfully loaded with the fluorescent receptor Chlorin e6 (Ce6) to prepare the luminescent nanoprobes (Ce6@Lum-AuNPs) with green synthesis, i.e., with biocompatible agents and mild temperature. The as-prepared fluorescent Ce6@Lum-AuNPs can efficiently and sensitively realize FL bioimaging of cancer cells. The relevant bio-sensing mechanism pertains to the presence of hypochlorite (ClO<superscript>−</superscript>); hydrogen peroxide (H<subscript>2</subscript>O<subscript>2</subscript>) in cancer cells could readily interact with luminol to produce chemiluminescence, which can activate the Ce6 component to emit near-infrared (NIR) FL. Therefore, this raises the possibility of utilizing the Ce6@Lum-AuNPs as efficient fluorescent nanoprobes for promising cancer early diagnosis and other relevant disease bioanalysis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20796374
- Volume :
- 12
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Biosensors (2079-6374)
- Publication Type :
- Academic Journal
- Accession number :
- 155497549
- Full Text :
- https://doi.org/10.3390/bios12020111