Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State.

Authors :: McEwen, Abbye E
Cohen, Seth
Bryson-Cahn, Chloe
Liu, Catherine
Pergam, Steven A
Lynch, John
Schippers, Adrienne
Strand, Kathy
Whimbey, Estella
Mani, Nandita S
Zelikoff, Allison J
Makarewicz, Vanessa A
Brown, Elizabeth R
Bakhash, Shah A Mohamed
Baker, Noah R
Castor, Jared
Livingston, Robert J
Huang, Meei-Li
Jerome, Keith R
Greninger, Alexander L
Source :: Clinical Infectious Diseases; 3/15/2022, Vol. 74 Issue 6, p1089-1092, 4p
Publication Year :: 2022
Abstract: Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1–23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections (P <.05). [ABSTRACT FROM AUTHOR]

Subjects :: IMMUNIZATION
GENETIC mutation
SEQUENCE analysis
CONFIDENCE intervals
COVID-19 vaccines
GENOMES
INFECTIOUS disease transmission
MESSENGER RNA
DESCRIPTIVE statistics
COVID-19 pandemic

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