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Label‐free Electrochemical Immunosensor for Sensitive Detection of Rheumatoid Arthritis Biomarker Anti‐CCP‐ab.
- Source :
- Electroanalysis; Apr2022, Vol. 34 Issue 4, p761-771, 11p
- Publication Year :
- 2022
-
Abstract
- The accurate and sensitive analysis of rheumatoid arthritis(RA) trace biomarkers is essential for early warning and diagnosis of RA, while anti‐cyclic citrullinated peptide antibody (anti‐CCP‐ab) is a specific one. In this study, a simple label‐free electrochemical immunosensor for the detection of anti‐CCP‐ab was constructed with nitrogen‐doped graphene (N−G) and gold nanoparticles (AuNPs). The proposed non‐enzyme immunosensor had exhibited high specificity, selectivity, and stability in the linear calibration curve range from 0.125∼2000 pg mL‐1 and has been successfully used in the detection of anti‐CCP‐ab in human serum, providing a new idea for the early diagnosis of RA. [ABSTRACT FROM AUTHOR]
- Subjects :
- RHEUMATOID arthritis
PEPTIDES
GOLD nanoparticles
BIOMARKERS
EARLY diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 10400397
- Volume :
- 34
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Electroanalysis
- Publication Type :
- Academic Journal
- Accession number :
- 156132083
- Full Text :
- https://doi.org/10.1002/elan.202100045