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Netpro2vec: A Graph Embedding Framework for Biomedical Applications.

Authors :
Manipur, Ichcha
Manzo, Mario
Granata, Ilaria
Giordano, Maurizio
Maddalena, Lucia
Guarracino, Mario R.
Source :
IEEE/ACM Transactions on Computational Biology & Bioinformatics; Mar/Apr2022, Vol. 19 Issue 2, p729-740, 12p
Publication Year :
2022

Abstract

The ever-increasing importance of structured data in different applications, especially in the biomedical field, has driven the need for reducing its complexity through projections into a more manageable space. The latest methods for learning features on graphs focus mainly on the neighborhood of nodes and edges. Methods capable of providing a representation that looks beyond the single node neighborhood are kernel graphs. However, they produce handcrafted features unaccustomed with a generalized model. To reduce this gap, in this work we propose a neural embedding framework, based on probability distribution representations of graphs, named Netpro2vec. The goal is to look at basic node descriptions other than the degree, such as those induced by the Transition Matrix and Node Distance Distribution. Netpro2vec provides embeddings completely independent from the task and nature of the data. The framework is evaluated on synthetic and various real biomedical network datasets through a comprehensive experimental classification phase and is compared to well-known competitors. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15455963
Volume :
19
Issue :
2
Database :
Complementary Index
Journal :
IEEE/ACM Transactions on Computational Biology & Bioinformatics
Publication Type :
Academic Journal
Accession number :
156272625
Full Text :
https://doi.org/10.1109/TCBB.2021.3078089