Phenolic compounds from the sclerotia of Inonotus obliquus.

Authors :: Wei, Yan-Mei
Yang, Li
Mei, Wen-Li
Chen, Hui-Qin
Cai, Cai-Hong
Li, Wei
Dong, Wen-Hua
Chen, Zhi-Bao
Dai, Hao-Fu
Source :: Natural Product Research; May2022, Vol. 36 Issue 9, p2413-2417, 5p
Publication Year :: 2022
Abstract: Three phenolic compounds (±1 and 2) including a pair of new enantiomers were isolated from the sclerotia of Inonotus obliquus. Their structures were assigned by extensive spectroscopic analyses. All the compounds were evaluated for the neuroprotective activity against oxidative damage on human neuroblastoma SH-SY5Y cells induced by H<subscript>2</subscript>O<subscript>2</subscript>. Compound 2 showed remarkable neuroprotective effect and significantly improved the cell viability of SH-SY5Y cells treated by H<subscript>2</subscript>O<subscript>2</subscript>. [ABSTRACT FROM AUTHOR]