Accelerated low‐density neutrophil transition in sickle cell anaemia may contribute to disease pathophysiology.

Inflammation, leucocytes, sickle cell disease, CD206, low-density neutrophils, vaso-occlusion Accelerated low-density neutrophil transition in sickle cell anaemia may contribute to disease pathophysiology Keywords: CD206; inflammation; leucocytes; low-density neutrophils; sickle cell disease; vaso-occlusion EN CD206 inflammation leucocytes low-density neutrophils sickle cell disease vaso-occlusion 232 235 4 04/19/22 20220415 NES 220415 Neutrophil plasticity is increasingly recognised, and granulocyte subsets such as the low-density neutrophils (LDNs) reportedly participate in self-resolving inflammation and cancer progression.1,2 Sickle cell anaemia (SCA) is an inherited haemolytic disorder associated with chronic inflammation SP S1 sp and extensive neutrophil functional heterogeneity, whereby augmented neutrophil recruitment to the vascular wall can play a triggering role in vaso-occlusive mechanisms.3-5 We aimed to determine whether normal-density neutrophil (NDN) to LDN transition is modulated in SCA, and to characterise this leucocyte subset further, with a view to determining a potential role in the disease's pathophysiology. [Extracted from the article]