Special Issue "Oxidative Stress in Aging and Associated Chronic Diseases".

The review describes how increased oxidative stress, cell senescence, and chronic inflammation promote cardiovascular and renal diseases as the paradigm of age-related chronic disease. They reported downregulated antioxidant levels and increased oxidative damage to lipids during aging, thereby suggesting oxidative stress as the original cause. Aging is a risk factor for several diseases, including cardiovascular disease, type 2 diabetes, hypertension, cancer, osteoarthritis, and Alzheimer; oxidative stress is a key player in the development and progression of aging and age-associated diseases. Interestingly, old mice fed with a low phosphate diet for three months showed improvement in vascular parameters, suggesting that dietary control of the phosphate intake diet could prevent premature vascular aging and delay aging-associated diseases such as vasculature aging. [Extracted from the article]