Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical trial.

Objectives: The aim of this study was to compare clinical, cytokine and microbiological responses after quadrant‐based scaling and root planing (Q‐SRP), full‐mouth SRP (FM‐SRP) and full‐mouth disinfection (FMD) in patients with generalized aggressive periodontitis (GAgP), which is currently termed as generalized stage‐III and grade‐C periodontitis. Methods: Forty‐two patients with GAgP were randomly assigned into groups as Q‐SRP, FM‐SRP or FMD with chlorhexidine. Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6 months after treatment. GCF levels of interleukin (IL)‐1β and IL‐17 were analysed using ELISA. Quantities of six bacterial species were determined using qPCR. Results: Clinical parameters improved significantly in all groups at 3 and 6 months (p < 0.05). Percentage of sites with probing depth >6 mm was lower in the FMD than Q‐SRP group at 3 and 6 months (p < 0.05). FMD showed significantly higher percentage of pocket closure compared with Q‐SRP and FM‐SRP at both 3 and 6 months after treatment (p < 0.05). The IL‐1β levels decreased only in the FMD group (p < 0.05), whereas no changes were found in IL‐17 levels in any group. The levels of five out of six bacterial species decreased at 3 and/or 6 months only in the FMD group (p < 0.05). Conclusions: The FMD treatment appears to offer superior outcome than Q‐SRP and could be the first choice for patients with GAgP. [ABSTRACT FROM AUTHOR]