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Synthesis of Highly Substituted 2‐Aminopyridines with Vinyl Azides, Isonitriles, and Ketones.
- Source :
- Chemistry - An Asian Journal; 5/2/2022, Vol. 17 Issue 9, p1-6, 6p
- Publication Year :
- 2022
-
Abstract
- We developed a facile, efficient method for synthesizing highly substituted 2‐aminopyridines from unstable vinyl carbodiimides generated in situ in a one‐pot transformation. A series of novel highly substituted 3‐functionalized 2‐aminopyridines were produced in good yields. Reaction mechanism studies, which included control experiments and density‐functional theory (DFT) calculations, demonstrated that Rh and potassium carbonate played key roles in the cyclization step. [ABSTRACT FROM AUTHOR]
- Subjects :
- ISOCYANIDES
AZIDES
KETONES
POTASSIUM carbonate
CARBODIIMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 17
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 156657763
- Full Text :
- https://doi.org/10.1002/asia.202200083