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Molecular Mechanisms of Coffee on Prostate Cancer Prevention.
- Source :
- BioMed Research International; 4/22/2022, p1-12, 12p
- Publication Year :
- 2022
-
Abstract
- Prostate cancer (PCa) is one of the most common types of cancer among men, and coffee is associated with a reduced risk of developing PCa. Therefore, we aim to review possible coffee molecular mechanisms that contribute to PCa prevention. Coffee has an important antioxidant capacity that reduces oxidative stress, leading to a reduced mutation in cells. Beyond direct antioxidant activity, coffee stimulates phase II enzymatic activity, which is related to the detoxification of reactive metabolites. The anti-inflammatory effects of coffee reduce tissue damage related to PCa development. Coffee induces autophagy, regulates the NF-κB pathway, and reduces the expression of iNOS and inflammatory mediators, such as TNF-α, IL-6, IL-8, and CRP. Also, coffee modulates transcriptional factors and pathways. It has been shown that coffee increases testosterone and reduces sex hormone-binding globulin, estrogen, and prostate-specific antigen. Coffee also enhances insulin resistance and glucose metabolism. All these effects may contribute to protection against PCa development. [ABSTRACT FROM AUTHOR]
- Subjects :
- GLUCOSE metabolism
INTERLEUKINS
COFFEE
GENETIC mutation
NITRIC-oxide synthases
SYSTEMATIC reviews
AUTOPHAGY
TESTOSTERONE
ESTROGEN
MOLECULAR biology
OXIDATIVE stress
CELLULAR signal transduction
TUMOR necrosis factors
MOLECULAR structure
INFLAMMATORY mediators
TRANSCRIPTION factors
GLOBULINS
PROSTATE-specific antigen
PROSTATE tumors
METABOLITES
INSULIN resistance
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- Complementary Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 156672917
- Full Text :
- https://doi.org/10.1155/2022/3254420