Commentary: Roles of the Cannabinoid System in the Basal Ganglia in Parkinson's Disease.

Keywords: cannabinoids; CB1 receptors; CB2 receptors; Parkinson's disease (PD); basal ganglia; RCT - randomized controlled trial; commentary articles EN cannabinoids CB1 receptors CB2 receptors Parkinson's disease (PD) basal ganglia RCT - randomized controlled trial commentary articles 1 3 3 05/12/22 20220509 NES 220509 Introduction This is a review article on the biological role of the cannabinoid system in the pathophysiology of Parkinson's disease (PD). CB1 receptors, Parkinson's disease (PD), cannabinoids, CB2 receptors, basal ganglia, RCT - randomized controlled trial, commentary articles Regarding the effects of CB1 on neurotransmission, enhanced CB1 receptor transmission in the striatum and in the output ganglia of globus pallidus (GP) internus/substantia nigra pars reticulata may alleviate PD symptoms, whereas if CB1 is activated in GP externus, it exacerbates PD symptoms (Wang et al., [6]). [Extracted from the article]