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Tumour-induced suppression of immune response and its correction.
- Source :
- Cancer Immunology, Immunotherapy; Jan2001, Vol. 49 Issue 11, p573-586, 14p
- Publication Year :
- 2001
-
Abstract
- Immunosuppressive features of tumour cells are a major obstacle for immunotherapy of cancer. We recently noted that RENCA cells effectively interfere with the in vivo activation of RENCA-specific T cells. To unravel the underlying mechanism, we evaluated the influence of RENCA cells on a mixed-lymphocyte/ tumour reaction as well as an allogeneic mixed-lymphocyte reaction. We observed that RENCA cells were not directly immunosuppressive. Instead, they initiated deviation of an immune response in at least two independent directions: (i) expansion of a population of NK1.1<superscript>+</superscript>/CD3<superscript>+</superscript> cells, which was accompanied by elimination of mainly CD4<superscript>+</superscript> lymphocytes, and (ii) production of a leukocyte-derived inhibitory factor. Expression of the costimulatory molecule B7.1 by RENCA cells prevented induction of anergy, while expression of MHC class II molecules prevented expansion of NK1.1<superscript>+</superscript> cells, which was accompanied by a significant decrease in cell death. Hence, an unimpaired response was observed only when RENCA cells expressed B7.1 plus MHC class II molecules. Thus, even if a tumour itself is not immunosuppressive, it can induce a strong deviation of the immune response. It is concluded that the first contact between elements of the immune system and the tumour cell can confer a severe bias on immunoregulatory circuits. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE response
IMMUNOLOGY
LYMPHOCYTES
LEUCOCYTES
CELL death
T cells
IMMUNE system
Subjects
Details
- Language :
- English
- ISSN :
- 03407004
- Volume :
- 49
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Cancer Immunology, Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 15681795
- Full Text :
- https://doi.org/10.1007/s002620000153