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Vaccination Against SARS-CoV-2 Is Associated With a Lower Viral Load and Likelihood of Systemic Symptoms.
- Source :
- Open Forum Infectious Diseases; May2022, Vol. 9 Issue 5, p1-9, 9p
- Publication Year :
- 2022
-
Abstract
- Background Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline viral load and symptoms between vaccinated and unvaccinated adults enrolled in a randomized trial of outpatient coronavirus disease 2019 (COVID-19) treatment. Methods Baseline data from the first 433 sequential participants enrolling into the COVID-OUT trial were analyzed. Adults aged 30–85 with a body mass index (BMI) ≥25 kg/m<superscript>2</superscript> were eligible within 3 days of a positive SARS-CoV-2 test and <7 days of symptoms. Log<subscript>10</subscript> polymerase chain reaction viral loads were normalized to human RNase P by vaccination status, by time from vaccination, and by symptoms. Results Two hundred seventy-four participants with known vaccination status contributed optional nasal swabs for viral load measurement: median age, 46 years; median (interquartile range) BMI 31.2 (27.4–36.4) kg/m<superscript>2</superscript>. Overall, 159 (58%) were women, and 217 (80%) were White. The mean relative log<subscript>10</subscript> viral load for those vaccinated <6 months from the date of enrollment was 0.11 (95% CI, –0.48 to 0.71), which was significantly lower than the unvaccinated group (P = .01). Those vaccinated ≥6 months before enrollment did not differ from the unvaccinated with respect to viral load (mean, 0.99; 95% CI, –0.41 to 2.40; P = .85). The vaccinated group had fewer moderate/severe symptoms of subjective fever, chills, myalgias, nausea, and diarrhea (all P < .05). Conclusions These data suggest that vaccination within 6 months of infection is associated with a lower viral load, and vaccination was associated with a lower likelihood of having systemic symptoms. [ABSTRACT FROM AUTHOR]
- Subjects :
- SARS-CoV-2
VIRAL load
CORONAVIRUS diseases
COVID-19
VACCINATION status
Subjects
Details
- Language :
- English
- ISSN :
- 23288957
- Volume :
- 9
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Open Forum Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 156842665
- Full Text :
- https://doi.org/10.1093/ofid/ofac066