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Transition-Metal-Catalyzed Decarbonylative Functionalization of Phthalimides.
- Source :
- Synthesis; Jun2022, Vol. 54 Issue 11, p2561-2573, 13p
- Publication Year :
- 2022
-
Abstract
- Phthalimide derivatives are prevalent in a wide array of biologically important molecules, including drugs, fungicides, and anticancer molecules. Thus, catalytic methods that directly edit the phthalimide moiety, in particular, decarbonylation and derivatization, could be strategically valuable for the modification of existing phthalimide molecular scaffolds. In recent years, considerable efforts have been devoted to emulating the transition-metal-catalyzed phthalimide decarbonylative reaction. A set of elegant strategies, including decarbonylative addition reactions with alkynes, alkenes, and benzynes, decarbonylative polymerization, alkylation, arylation, and protodecarbonylation, have been demonstrated. This review aims to highlight these advances and discusses the mechanism issues, to further expand application and promote developments in this field. 1 Introduction 2 Decarbonylative Addition Reaction with Alkynes 3 Decarbonylative Addition Reaction with Alkenes 4 Decarbonylative Addition Reaction with Benzyne 5 Decarbonylative Polymerization 6 Decarbonylative Alkylation 7 Decarbonylative Arylation 8 Protodecarbonylation 9 Conclusion and Outlook [ABSTRACT FROM AUTHOR]
- Subjects :
- PHTHALIMIDES
ADDITION reactions
ALKYLATION
DECARBONYLATION
DERIVATIZATION
BENZYNES
Subjects
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 54
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 156896451
- Full Text :
- https://doi.org/10.1055/a-1751-1929