Back to Search Start Over

Transition-Metal-Catalyzed Decarbonylative Functionalization of Phthalimides.

Authors :
Liu, Ying-Ying
Sun, Shao-Han
Min, Xiang-Ting
Wan, Boshun
Chen, Qing-An
Source :
Synthesis; Jun2022, Vol. 54 Issue 11, p2561-2573, 13p
Publication Year :
2022

Abstract

Phthalimide derivatives are prevalent in a wide array of biologically important molecules, including drugs, fungicides, and anticancer molecules. Thus, catalytic methods that directly edit the phthalimide moiety, in particular, decarbonylation and derivatization, could be strategically valuable for the modification of existing phthalimide molecular scaffolds. In recent years, considerable efforts have been devoted to emulating the transition-metal-catalyzed phthalimide decarbonylative reaction. A set of elegant strategies, including decarbonylative addition reactions with alkynes, alkenes, and benzynes, decarbonylative polymerization, alkylation, arylation, and protodecarbonylation, have been demonstrated. This review aims to highlight these advances and discusses the mechanism issues, to further expand application and promote developments in this field. 1 Introduction 2 Decarbonylative Addition Reaction with Alkynes 3 Decarbonylative Addition Reaction with Alkenes 4 Decarbonylative Addition Reaction with Benzyne 5 Decarbonylative Polymerization 6 Decarbonylative Alkylation 7 Decarbonylative Arylation 8 Protodecarbonylation 9 Conclusion and Outlook [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00397881
Volume :
54
Issue :
11
Database :
Complementary Index
Journal :
Synthesis
Publication Type :
Academic Journal
Accession number :
156896451
Full Text :
https://doi.org/10.1055/a-1751-1929