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A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro.
- Source :
- Journal of Asian Natural Products Research; Jun2022, Vol. 24 Issue 6, p577-588, 12p
- Publication Year :
- 2022
-
Abstract
- Dimethyl itaconate (DMI) is an analog of dimethyl fumarate (DMF), an approved NF-E2-related Factor 2 (Nrf2) activator for multiple sclerosis. This study evaluated the potential of DMI as an anti-inflammatory agent by comparing DMI with DMF in electrophilicity, Nrf2 activation, and anti-inflammation in vitro. The results showed that DMI was less electrophilic but better at inducing a durable activation of Nrf2 when compared with DMF. However, DMI demonstrated poor anti-inflammatory effects in Jurkat cells, bone marrow-derived dendritic cells, and RAW264.7 cells. Our study suggested that DMI was a potent electrophilic Nrf2 activator but was probably not a promising anti-inflammatory agent. [ABSTRACT FROM AUTHOR]
- Subjects :
- IN vitro studies
ANTI-inflammatory agents
TIME
WESTERN immunoblotting
QUANTITATIVE research
ANTIOXIDANTS
OXIDATIVE stress
COMPARATIVE studies
CELLULAR signal transduction
GENE expression
DOSE-effect relationship in pharmacology
DESCRIPTIVE statistics
RESEARCH funding
IMMUNOLOGIC diseases
MOLECULAR structure
REACTIVE oxygen species
T cells
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 24
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 156916698
- Full Text :
- https://doi.org/10.1080/10286020.2021.1949303