"Co-relation of MRI findings in new onset seizure patients presenting to tertiary care centre" A prospective study from central India.

Background: The term seizure is used to describe abnormal, uncontrolled paroxysmal electrical activity of brain, literature suggests that about 8 -10% of population may experience at least one episode of seizure. In adult patients with new onset seizures, neuroimaging studies like MRI brain are advised to find out the underlying cause, structural abnormality, and the likelihood of recurrence. For neuroimaging, CT scan and MRI both can be done but for detection of cerebral lesions, imaging with MRI is considered superior to CT scan. MRI becomes essential, because of its superior depiction of brain anatomy and tissue composition. Aims and Objectives: To Evaluate the MRI brain study in new onset seizure and to identify a lesion in MRI brain that can explain the seizure. Materials and methods: sixty-nine patients (age 18 and above with new onset seizures) were studied in the out-patient and in-patient department of medicine of a tertiary care centre of central India from 1st July 2019 to 30th June 2021. All patients fulfilling inclusion criteria were subjected to detailed clinical history, examination including neurological examination, and etiology and characteristics of seizure were co related with MRI brain findings. Results: The majority of patients were presented with focal seizures 38(55%)and with generalized seizure 31(45%). Seizures are more prevalent in age 18 to 40 years. The prevalence of seizures was higher in males (60%) than in females (40%). MRI brain revealed abnormal findings on 68.1% cases with new onset seizures. MRI revealed CVA in 17.3% cases (infarct in 13% and bleed in 4.3%), tuberculoma in 7.2% and neurocysticercosis in 5.8% cases, viral and tubercular meningitis in 4.3% cases each, Cortical Venous Thrombosis was noted in 8.7% cases, AV Malformations, Mesial temporal lobe sclerosis, Posterior reversible encephalopathy syndrome (PRES) and Dyke Davidoff Masson Syndrome were noted in 2.9% cases each. [ABSTRACT FROM AUTHOR]