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Silver‐catalysed A3‐coupling reactions in phenylacetic acid/alkylamine N‐oxide eutectic mixture under dielectric heating: An alternative approach to propargylamines.

Silver‐catalysed A3‐coupling reactions in phenylacetic acid/alkylamine N‐oxide eutectic mixture under dielectric heating: An alternative approach to propargylamines.

Authors :
Brambilla, Elisa
Bortolla, Alison
Pirovano, Valentina
Caselli, Alessandro
Tiecco, Matteo
Abbiati, Giorgio
Source :
Applied Organometallic Chemistry; Jun2022, Vol. 36 Issue 6, p1-10, 10p
Publication Year :
2022

Abstract

The development of alternative benign reaction conditions to perform multicomponent reactions is an interesting and desirable strategy to increase the sustainability of organic synthesis. In this paper, we report a new version of A3‐coupling MCR for the preparation of differently substituted propargylamines starting from aldehydes, alkynes and amines in an acidic DES as reaction media, under dielectric heating, and in the presence of a tetraaza‐macrocyclic silver complex as catalyst. The reaction scope is broad in terms of aldehyde partners. Electron‐rich phenylacetylenes are the more reactive alkynes partners, whereas the nature of the amine is the more serious limitation as only secondary cyclic amines are tolerated. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02682605
Volume :
36
Issue :
6
Database :
Complementary Index
Journal :
Applied Organometallic Chemistry
Publication Type :
Academic Journal
Accession number :
156968699
Full Text :
https://doi.org/10.1002/aoc.6669