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Palladium-catalyzed carboxylative cyclization of propargylic amines with aryl iodides, CO2 and CO under ambient pressure.
- Source :
- Chemical Communications; 5/28/2022, Vol. 58 Issue 43, p6332-6335, 4p
- Publication Year :
- 2022
-
Abstract
- A palladium-catalyzed four-component carboxylative cyclization comprising propargylic amines, aryl iodides, CO<subscript>2</subscript> and CO was developed. By selecting Et<subscript>3</subscript>N and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the base, respectively, both terminal and internal propargylic amines proceeded well facilitated by Pd(PPh<subscript>3</subscript>)<subscript>2</subscript>Cl<subscript>2</subscript>, affording the functionalized 2-oxazolones in moderate yields. This protocol enlarges the product diversity based on CO<subscript>2</subscript> conversion and simultaneously provides a cooperative transformation route for both CO<subscript>2</subscript> and CO. [ABSTRACT FROM AUTHOR]
- Subjects :
- AROMATIC amines
ARYL iodides
RING formation (Chemistry)
AMINES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 43
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 157125772
- Full Text :
- https://doi.org/10.1039/d2cc01635d