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A Flexible Paper-based Electrochemical Immunosensor Towards Detection of Carbohydrate Antigen 15-3.
- Source :
- Analytical & Bioanalytical Electrochemistry; May2022, Vol. 14 Issue 5, p445-454, 10p
- Publication Year :
- 2022
-
Abstract
- In this paper, we developed a simple and disposable electrochemical paper-based immunosensor (e-PI) based on manual screen printing method via patterned sticker label film on paper. The proposed electrochemical sensors provide the opportunity for economical singleuse analysis of biological samples. The e-PI was constructed with hydrophobic glossy paper layers on a wax paper substrate to define three-electrode system. A carbon ink was used for construction of e-PI which composed of the graphite powder and cellulose acetate. The stability of the e-PI was evaluated using electrochemical methods. Carbohydrate antigen 15-3 (CA15-3) antibodies to the target CA15-3 antigen were immobilized on gold-modified graphite electrodes on the e-PI. Electrochemical properties of e-PI were investigated by cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. The fabricated e-PI offers a vast linear range from 0.5 to 200 U mL-1 with a low limit of detection 0.15 U mL-1. Furthermore, the fabricated e-PI has acceptable stability, accuracy and high sensitivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20084226
- Volume :
- 14
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Analytical & Bioanalytical Electrochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 157317667