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MicroRNA-365a/b-3p as a Potential Biomarker for Hypertrophic Scars.

MicroRNA-365a/b-3p as a Potential Biomarker for Hypertrophic Scars.

Authors :
Lee, Joon Seok
Kim, Gyeong Hwa
Lee, Jong Ho
Ryu, Jeong Yeop
Oh, Eun Jung
Kim, Hyun Mi
Kwak, Suin
Hur, Keun
Chung, Ho Yun
Source :
International Journal of Molecular Sciences; Jun2022, Vol. 23 Issue 11, p6117-6117, 12p
Publication Year :
2022

Abstract

The clinical aspects of hypertrophic scarring vary according to personal constitution and body part. However, the mechanism of hypertrophic scar (HS) formation remains unclear. MicroRNAs (miRNAs) are known to contribute to HS formation, however, their detailed role remains unknown. In this study, candidate miRNAs were identified and analyzed as biomarkers of hypertrophic scarring for future clinical applications. HSfibroblasts and normal skin fibroblasts from patients were used for profiling and validation of miRNAs. An HS mouse model with xenografted human skin on nude mice was established. The miRNA expression between normal human, normal mouse, and mouse HS skin tissues was compared. Circulating miRNA expression levels in the serum of normal mice and mice with HSs were also analyzed. Ten upregulated and twenty-one downregulated miRNAs were detected. Among these, miR-365a/b-3p and miR-16-5p were identified as candidate miRNAs with statistically significant differences; miR-365a/b-3p was significantly upregulated (p = 0.0244). In mouse studies, miR-365a/b-3p expression levels in skin tissue and serum were higher in mice with HSs than in the control group. These results indicate that miRNAs contribute to hypertrophic scarring and that miR-365a/b-3p may be considered a potential biomarker for HS formation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
23
Issue :
11
Database :
Complementary Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
157373183
Full Text :
https://doi.org/10.3390/ijms23116117