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Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil.
- Source :
- Natural Product Research; Jun2022, Vol. 36 Issue 11, p2878-2883, 6p
- Publication Year :
- 2022
-
Abstract
- The chemical composition of Gallesia integrifolia fruits essential oil was obtained by hydrodistillation using a modified Clevenger apparatus was investigated by gas chromatography coupled to mass spectrometry (GC/MS). In addition, the cytotoxicity activity against human tumor cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (large cell lung carcinoma), HeLa (cervical carcinoma), and HepG2 (hepatocellular carcinoma), and non-tumor PLP2 (porcine liver primary cells) as well as the anti-inflammatory action was proposal. The compounds were predominantly organosulfates (2,8-dithianonane, dimethyl trisulfide, and lenthionine). Anti-inflammatory activity that provides 50% inhibition of nitric oxide production (55 µg/mL) of essential oil of the fruits. It also presents cytotoxic activity against MCF-7 (GI<subscript>50</subscript> = 66 µg/mL), NCI-H-460 (GI<subscript>50</subscript> = 147 µg/mL), HeLa (GI<subscript>50</subscript> = 182 µg/mL) and HepG2 (GI<subscript>50</subscript> = 240 µg/mL). The essential oil is more active in tumor cells than in non-tumor cells and the GI<subscript>50</subscript> values for essential oil reported in our work support future studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 36
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 157383841
- Full Text :
- https://doi.org/10.1080/14786419.2021.1925270