Ocular involvement in patients with primary central‐nervous‐system lymphoma: Analysis of a multicentre study in Spain.

Intraocular involvement in patients with primary central-nervous-system lymphoma (oPCNSL) usually affects the retina, vitreous or optic nerve and can occur in isolation or, more commonly, in association with brain lymphoma.1,2 It has been estimated that 10%-25% of patients with PCNSL have ocular dissemination at diagnosis.3 For these reasons, an ophthalmic examination at diagnosis is highly recommended. In five out of the 26 (19%) patients, ocular symptoms, usually described as a decrease in visual acuity, preceded the CNS symptoms. In the oPCNSL group, diagnosis of PCNSL was done by vitrectomy (three patients) or brain biopsy (23 patients). [Extracted from the article]