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Outcomes of successful vs. failed contemporary chronic total occlusion percutaneous coronary intervention.

Authors :
Megaly, Michael
Khalil, Mahmoud
Basir, Mir B.
McEntegart, Margaret B.
Spratt, James C.
Yamane, Masahisa
Tsuchikane, Etsuo
Xu, Bo
Alaswad, Khaldoon
Brilakis, Emmanouil S.
Source :
Cardiovascular Intervention & Therapeutics; Jul2022, Vol. 37 Issue 3, p483-489, 7p
Publication Year :
2022

Abstract

Background: There are limited contemporary data on the impact of success vs. failure on the outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Methods: We conducted a systematic review and a meta-analysis of contemporary studies that compared the outcomes in patients who underwent successful vs. failed contemporary (2010 onwards) CTO PCI. We performed a sensitivity analysis limited to studies that started enrollment after the publication of the hybrid algorithm in 2012. Results: We included five studies with a total of 6,084 patients (successful CTO PCI n = 4,861, failed CTO PCI n = 1,223). During a median follow-up time of 12 months (range 6–60 months), successful CTO PCI was associated with a lower risk of major adverse cardiovascular events [OR: 0.61, 95% CI (0.41, 0.92), p = 0.02, I<superscript>2</superscript> = 63%] and all-cause death [OR: 0.57, 95% CI (0.33, 0.99), p = 0.05, I<superscript>2</superscript> = 60%]. Both groups had similar risk of myocardial infarction (MI) [OR 0.69, 95% CI (0.43, 1.10), p = 0.38, I<superscript>2</superscript> = 80%], target vessel revascularization (TVR) [OR: 0.56, 95% CI (0.25, 1.27), p = 0.17, I<superscript>2</superscript> = 80%], and stroke [OR: 0.52, 95% CI (0.14, 1.91), p = 0.33, I<superscript>2</superscript> = 0%]. Conclusion: In contemporary practice, successful CTO PCI was associated with a lower incidence of MACE driven by lower all-cause mortality compared with failed CTO PCI at a median follow-up of 1 year. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18684300
Volume :
37
Issue :
3
Database :
Complementary Index
Journal :
Cardiovascular Intervention & Therapeutics
Publication Type :
Academic Journal
Accession number :
157431882
Full Text :
https://doi.org/10.1007/s12928-021-00819-x