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An efficient domino strategy for synthesis of 3-substituted 4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine derivatives in water.
- Source :
- Molecular Diversity; Jun2022, Vol. 26 Issue 3, p1663-1674, 12p
- Publication Year :
- 2022
-
Abstract
- A strategy for catalyst-free domino reaction of 4-aminopyridin-2(1H)-ones, arylglyoxal hydrates and different 1,3-dicarbonyl compounds in water has been established. The mild and efficient procedure afforded pyrrolo[3,2-c]pyridine derivatives with 76–94% yields after simple crystallization. The present procedure shows promising characteristics, such as readily available starting materials, the use of water as reaction media, simple and efficient one-pot operation, and avoiding the need for any hazardous or expensive catalysts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13811991
- Volume :
- 26
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Molecular Diversity
- Publication Type :
- Academic Journal
- Accession number :
- 157545453
- Full Text :
- https://doi.org/10.1007/s11030-021-10294-4