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PHOSPHATE exporter XPR1/SLC53A1 is required for the tumorigenicity of epithelial ovarian cancer.
- Source :
- Cancer Science; Jun2022, Vol. 113 Issue 6, p2034-2043, 10p
- Publication Year :
- 2022
-
Abstract
- Ovarian cancer is the fifth most common cause of cancer‐related death in women. Ovarian clear cell carcinoma (OCCC) is a chemotherapy‐resistant epithelial ovarian cancer with poor prognosis. As a basis for the development of therapeutic agents that could improve the prognosis of OCCC, we performed a screen for proteins critical for the tumorigenicity of OCCC using the CRISPR/Cas9 system. Here we show that knockdown of the phosphate exporter XPR1/SLC53A1 induces the growth arrest and apoptosis of OCCC cells in vitro. Moreover, we show that knockdown of XPR1/SLC53A1 inhibits the proliferation of OCCC cells xenografted into immunocompromised mice. These results suggest that XPR1/SLC53A1 plays a critical role in the tumorigenesis of OCCC cells. We speculate that XPR1/SLC53A1 might be a promising molecular target for the therapeutic treatment of OCCC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13479032
- Volume :
- 113
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Cancer Science
- Publication Type :
- Academic Journal
- Accession number :
- 157549184
- Full Text :
- https://doi.org/10.1111/cas.15358