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Synthesis of allylanilines via scandium-catalysed benzylic C(sp3)–H alkenylation with alkynes.
- Source :
- Chemical Communications; 7/4/2022, Vol. 58 Issue 52, p7257-7260, 4p
- Publication Year :
- 2022
-
Abstract
- The ortho-selective benzylic C(sp<superscript>3</superscript>)–H alkenylation of 2-methyl tertiary anilines with internal alkynes has been achieved for the first time by using a half-sandwich scandium catalyst. This protocol provides a straightforward route for the synthesis of a new family of 2-allylaniline derivatives, featuring broad substrate scope, 100% atom-efficiency, high yields, and high chemo-, regio-, and stereoselectivity. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALKENYLATION
SCANDIUM catalysts
ALKYNES
STEREOSELECTIVE reactions
ANILINE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 52
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 157687481
- Full Text :
- https://doi.org/10.1039/d2cc02489f