Defective α‐tectorin may involve tectorial membrane in familial Meniere disease.

In this study, the presence of rare missense variants and frame shift deletions in the I TECTA i gene in six unrelated families with MD suggests a role of this gene in the pathophysiology of the disease. Three rare missense variants (colored in blue) and two short deletions (colored in red) were found in four multicase MD families (arrow shaped) and two additional families with one MD patient and relatives with partial syndromes (diamond shaped). Dear Editor Although there have been considerable advances in recent years, the contribution of genetic factors to Meniere's disease (MD) is not yet fully understood. [Extracted from the article]