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Targeting Metabolic Reprogramming of T-Cells for Enhanced Anti-Tumor Response.
- Source :
- Biologics: Targets & Therapy; May2022, Vol. 16, p35-45, 11p
- Publication Year :
- 2022
-
Abstract
- Cancer immunotherapy is an effective treatment option against cancer. One of the approaches of cancer immunotherapy is the modification of T cell-based anti-tumor immune responses. T-cells, a type of adaptive immune response cells responsible for cell-mediated immunity, have long been recognized as key regulators of immune-mediated anti-tumor immunity. T-cell activities have been reported to be suppressed or enhanced by changes in cell metabolism. Moreover, metabolic reprogramming during activation of T cells is required for the development of distinct differentiation profiles of these cells, which may allow the development of long-term cell-mediated anti-tumor immunity. However, T cells have been shown to undergo metabolic exhaustion in tumor microenvironment (TME) as it poses several obstacles to their function. Applications of several mechanistic solutions to improve the efficacy of T cell-based therapies including chimeric antigen receptor (CAR) T cell therapy are yet to be determined. Modifying the metabolic properties of these cells and employing them in cancer immunotherapy is a potential strategy for improving their anti-tumor activity and therapeutic efficacy. To give an insight, in this review paper, we endeavoured to cover metabolic reprogramming in cancer and T cells, signalling mechanisms involved in immuno-metabolic regulation, the effects of the TME on T cell metabolic fitness, and targeting metabolic reprogramming of T cells for an enhanced anti-tumor response. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11775475
- Volume :
- 16
- Database :
- Complementary Index
- Journal :
- Biologics: Targets & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 157838654
- Full Text :
- https://doi.org/10.2147/BTT.S365490