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RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection.

Authors :
Lewitus, Eric
Sanders-Buell, Eric
Bose, Meera
O'Sullivan, Anne Marie
Poltavee, Kultida
Li, Yifan
Bai, Hongjun
Mdluli, Thembi
Donofrio, Gina
Slike, Bonnie
Zhao, Hong
Wong, Kim
Chen, Lennie
Miller, Shana
Lee, Jenica
Ahani, Bahar
Lepore, Steven
Muhammad, Sevan
Grande, Rebecca
Tran, Ursula
Source :
Virus Evolution; Dec2021, Vol. 7 Issue 2, p1-13, 13p
Publication Year :
2021

Abstract

The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1's high evolvability hints that HIV-1 could adapt to a future vaccine. Here, we wanted to investigate the effect of vaccination on the evolution of the virus post-breakthrough infection. We analyzed 2,635 HIV-1 env sequences sampled up to a year post-diagnosis from 110 vaccine and placebo participants who became infected in the RV144 vaccine efficacy trial. We showed that the Env signature sites that were previously identified to distinguish vaccine and placebo participants were maintained over time. In addition, fewer sites were under diversifying selection in the vaccine group than in the placebo group. These results indicate that HIV-1 would possibly adapt to a vaccine upon its roll-out. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20571577
Volume :
7
Issue :
2
Database :
Complementary Index
Journal :
Virus Evolution
Publication Type :
Academic Journal
Accession number :
157843444
Full Text :
https://doi.org/10.1093/ve/veab057