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Anergy and Suppression in B-Cell Responses.
- Source :
- Scandinavian Journal of Immunology; Dec1992, Vol. 36 Issue 6, p761-767, 7p
- Publication Year :
- 1992
-
Abstract
- Two main ideas have been put forward lo explain the unexpectedly low anti-hapten antibody titres which can result from pre-priming a mouse with carrier before hapten-carrier immunization. The first involves the interaction of a network of idiotype-specific suppressor T cells, the second instead arguing for the role of intrinsie B-cell anergy. This paper proposes that the data available can equally be interpreted as reflecting the suboptimal interaction between T and B cells at differing stages of maturity, provided that memory B cells can be divided into two subsets. Further, it is suggested that these considerations must be taken into account in the analysis of B-cell anergy in receptor transgenic mice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009475
- Volume :
- 36
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Scandinavian Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15799749
- Full Text :
- https://doi.org/10.1111/j.1365-3083.1992.tb03137.x