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Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights.

Authors :
Sorohan, Bogdan Marian
Baston, Cătălin
Tacu, Dorina
Bucșa, Cristina
Țincu, Corina
Vizireanu, Paula
Sinescu, Ioanel
Constantinescu, Ileana
Source :
Biomedicines; Jul2022, Vol. 10 Issue 7, pN.PAG-N.PAG, 15p
Publication Year :
2022

Abstract

The polymorphic human leukocyte antigen (HLA) system has been considered the main target for alloimmunity, but the non-HLA antibodies and autoimmunity have gained importance in kidney transplantation (KT). Apart from the endothelial injury, secondary self-antigen exposure and the presence of polymorphic alloantigens, respectively, auto- and allo- non-HLA antibodies shared common steps in their development, such as: antigen recognition via indirect pathway by recipient antigen presenting cells, autoreactive T cell activation, autoreactive B cell activation, T helper 17 cell differentiation, loss of self-tolerance and epitope spreading phenomena. Both alloimmunity and autoimmunity play a synergic role in the formation of non-HLA antibodies, and the emergence of transcriptomics and genome-wide evaluation techniques has led to important progress in understanding the mechanistic features. Among them, non-HLA mismatches between donors and recipients provide valuable information regarding the role of genetics in non-HLA antibody immunity and development. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22279059
Volume :
10
Issue :
7
Database :
Complementary Index
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
158212176
Full Text :
https://doi.org/10.3390/biomedicines10071506