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Total Synthesis of Kibdelomycin.
- Source :
- Angewandte Chemie International Edition; 8/8/2022, Vol. 61 Issue 32, p1-6, 6p
- Publication Year :
- 2022
-
Abstract
- A modular total synthesis of kibdelomycin is disclosed that should enable structure–activity relationship (SAR) studies of this interesting class of antibiotics. The route uses simple building blocks and addresses lingering questions about its structural assignment and relationship to amycolamicin, a recently described natural product reported to have a similar structure. Initial antibacterial assays reveal that both C‐22 epimers (the N‐glycosidic linkage) of the natural product have similar activity while structurally truncated analogs lose activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- NATURAL products
STRUCTURE-activity relationships
ANTIBIOTICS
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 61
- Issue :
- 32
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 158287064
- Full Text :
- https://doi.org/10.1002/anie.202206183