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Silver‐Promoted Decarboxylative Difluoromethylenation of α,β‐Unsaturated Carboxylic Acids for the Synthesis of Allylic Difluorides.
- Source :
- Chemistry - An Asian Journal; Aug2022, Vol. 17 Issue 15, p1-6, 6p
- Publication Year :
- 2022
-
Abstract
- An efficient silver‐promoted decarboxylative gem‐difluoromethylenation of aryl‐ or alkyl‐substituted α,β‐unsaturated carboxylic acids with readily available benzo‐1,3‐diazolic difluoromethyl bromides has been developed. This convenient transformation demonstrated good functional‐group tolerability and broad substrate scope, and afforded the allylic difluorides in good to excellent yields with exclusive E‐stereoselectivity under mild reaction conditions. [ABSTRACT FROM AUTHOR]
- Subjects :
- CARBOXYLIC acids
ARYL bromides
BROMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 17
- Issue :
- 15
- Database :
- Complementary Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 158287220
- Full Text :
- https://doi.org/10.1002/asia.202200448