LncRNAs harbouring regulatory motifs within repeat elements modulate immune response towards COVID‐19 disease severity and clinical outcomes.

Large cluster of 16 lncRNAs (lnc-STIM2-7:1, lnc-MSH3-2:1, lnc-KCNE1B-3:5, lnc-IRS4-2:1, lnc-PRR32-4:2, lnc-MYO16-7:1, lnc-UTY-17:1, lnc-KCNE1B-155:1, lnc-KCNE1B-3:3, LINC00273:1, lnc-GPR39-10:2, lnc-TMEM132C-11:1, lnc-KCNE1B-3:2, lnc-KCNE1B-3:4, LINC00273:11, LINC00273:13) was obtained downregulated in mortality patients, suggesting possible association of these lncRNAs with COVID-19 mortality. To understand role of lncRNAs in modulating host response in the patients who succumbed to COVID-19, we performed differential expression analysis between recovered and mortality patients. LncRNAs harbouring regulatory motifs within repeat elements modulate immune response towards COVID-19 disease severity and clinical outcomes. [Extracted from the article]