WITH CRISPR/CAS9, FIGHTING AGAINST THE DARK EMPIRE OF DISEASES.

Clustered Regularly InterSpaced Palindromic Repeats is what CRISPR stands for. This is a protein that is programmable and can edit, eliminate, or turn the genome on or off. This is a modern technology that can have many potential applications and can change the future of oral health for the better. Genome editing technologies can be used to create mutations in the genomes based on a set of sequence-specific instructions, including, clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPRassociated protein 9 (Cas9), transcription activator-like effector nucleases (TALENs), zinc finger nucleases (ZFNs), and homing endonucleases or meganucleases. CRISPR-Cas9 genome editing technology is very young, but it has emerged in recent years as a powerful tool in cancer therapy for its high efficiency and accuracy. The CRISPR-Cas9 system uses gene editing in cells, organs and animals to access entire genomes within a short period of time, both gene-editing for gain-of-function and gene-editing for loss-of-function. Methods of detection based on CRISPR/Cas by the near future may become simpler, more affordable, and faster. Here, we review the application of CRISPR-Cas9 genome editing in dentistry, as well as its general advantages and disadvantages. [ABSTRACT FROM AUTHOR]