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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.
- Source :
- British Journal of Cancer; Aug2022, Vol. 127 Issue 3, p514-523, 10p
- Publication Year :
- 2022
-
Abstract
- <bold>Background: </bold>Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities.<bold>Methods: </bold>We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 µm radius (to derive T cell proximity score).<bold>Results: </bold>High T cell proximity score associated with longer cancer-specific survival in both the study cohort [adjusted HR for high (vs. low) 0.33, 95% CI 0.20-0.52, Ptrend < 0.0001] and the validation cohort [adjusted HR for high (vs. low) 0.15, 95% CI 0.05-0.45, Ptrend < 0.0001] and its prognostic value was independent of T cell density score.<bold>Conclusions: </bold>The spatial point pattern analysis of tumour cell-T cell co-localisation could provide detailed information on colorectal cancer prognosis, supporting the value of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROGNOSIS
COLORECTAL cancer
LYMPHOCYTES
RESEARCH funding
T cells
LYMPHOCYTE count
Subjects
Details
- Language :
- English
- ISSN :
- 00070920
- Volume :
- 127
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- British Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 158311815
- Full Text :
- https://doi.org/10.1038/s41416-022-01822-6