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impact of pre-treatment muscle strength and physical performance on treatment modification in older adults with cancer following comprehensive geriatric assessment.
- Source :
- Age & Ageing; Jul2022, Vol. 51 Issue 7, p1-5, 5p, 2 Charts
- Publication Year :
- 2022
-
Abstract
- Background Grip strength (GS) and the short physical performance battery (SPPB) have been shown to predict clinical outcomes in older adults with cancer. However, whether pre-treatment GS and SPPB impact treatment decisions following comprehensive geriatric assessment (CGA) is poorly understood. Our objective was to assess the impact of low GS and/or SPPB on treatment modification to initially proposed treatment plans in older adults with cancer following CGA. Methods This was a retrospective cohort study of older adults who had undergone CGA before receiving cancer treatment. Data were retrieved from a prospective database in an academic cancer centre and medical records. Treatment modification following CGA was defined as reduced treatment intensity or transition from active treatment to supportive care. Multivariable logistic regression assessed the impact of pre-treatment GS and SPPB on treatment modification following CGA. Results In total, 515 older adults (mean age: 80.7y) who had undergone CGA prior to cancer treatment were included. Low muscle strength and/or physical performance was observed in 66.4% of participants. Treatment was modified in 49.5% of the cohort following CGA. Low GS and/or SPPB combined was predictive of treatment modification (OR = 1.77, 95%CI = 1.07–2.90, P = 0.025) in multivariable analysis. Additional predictors of treatment modification included palliative treatment intent, comorbidities and malnutrition. Conclusions Low GS and/or SPPB combined prior to cancer treatment predicts treatment modification in older adults with cancer and may be useful in treatment decision-making. Management of poor muscle strength and physical performance should be offered to optimize patient care and potentially improve treatment outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- TUMOR treatment
GRIP strength
ACADEMIC medical centers
CONFIDENCE intervals
MULTIVARIATE analysis
GERIATRIC assessment
RETROSPECTIVE studies
ACQUISITION of data
CANCER patients
MUSCLE strength
BODY movement
MEDICAL records
DESCRIPTIVE statistics
DECISION making in clinical medicine
ELECTRONIC health records
LOGISTIC regression analysis
ODDS ratio
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 00020729
- Volume :
- 51
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Age & Ageing
- Publication Type :
- Academic Journal
- Accession number :
- 158324086
- Full Text :
- https://doi.org/10.1093/ageing/afac152