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Sequence analysis of Epstein–Barr virus BALF2 gene in associated tumors and healthy individuals from southern and northern China.
- Source :
- Future Virology; Sep2022, Vol. 17 Issue 9, p617-626, 10p
- Publication Year :
- 2022
-
Abstract
- Aim: The purpose of this study is to investigate the polymorphism and distribution characteristics of BALF2 gene in Epstein–Barr virus (EBV)-associated tumors (gastric cancer, nasopharyngeal carcinoma and lymphoma). Materials & methods: DNA sequences of 349 EBV-related samples were analyzed by nested PCR combined with DNA sequencing. Results: According to the phylogenetic tree, BALF2 was divided into six genotypes (BALF2-A–F). Statistically, the incidence of BALF2-E in nasopharyngeal carcinoma was higher than that in healthy people, and the incidence of BALF2-E in nasopharyngeal carcinoma in South China was higher than that in North China (p = 0.001). Conclusion:BALF2 variants in EBV-associated samples are not only tumor-specific, but also differ between northern and southern regions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17460794
- Volume :
- 17
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Future Virology
- Publication Type :
- Academic Journal
- Accession number :
- 158570070
- Full Text :
- https://doi.org/10.2217/fvl-2021-0177