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Characterizing DRESS syndrome recurrence: a systematic review.
- Source :
- Archives of Dermatological Research; Oct2022, Vol. 314 Issue 8, p721-728, 8p
- Publication Year :
- 2022
-
Abstract
- Recurrence of DRESS syndrome is poorly characterized, and dermatologists must be prepared to predict, identify, and manage patients after treatment of the initial presentation. In this study, a primary literature search was conducted using PubMed, capturing all articles recording cases of DRESS syndrome recurrence. Forty-two articles were included for review comprising a total of 60 patients. The average age of patients was 46.3 years and time to recurrence was 123 days. Recurrent episodes presented more frequently with a higher fever and eosinophil absolute peak. Relapse was most often attributed to the introduction of a new medication (n = 18). Of the 17 cases in which outcome data were available, the survival rate of those experiencing recurrence was 71%. Viral reactivation with HHV-6 and organ involvement of the liver were frequently recorded complications. In essence, viral reactivation, severe internal organ involvement, and hematological abnormalities all portended a poorer prognosis in those experiencing DRESS syndrome recurrence. An adequate course of treatment should be maintained until clinical and laboratory parameters normalize, with a slow taper to minimize the likelihood of relapse in those most at risk. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03403696
- Volume :
- 314
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Archives of Dermatological Research
- Publication Type :
- Academic Journal
- Accession number :
- 158671577
- Full Text :
- https://doi.org/10.1007/s00403-021-02274-3