Oncocytic variant of adrenocortical carcinoma: A rare entity.

It is critical to extensively sample an OAN as one should discriminate a pure oncocytic tumor either from an ordinary adrenocortical tumor with focal oncocytic changes or its conventional counterpart of the compact cell type in order not to incorrectly apply the Weiss system and accordingly inadequately estimate its biological behavior. Also, an oncocytic tumor can only be labeled as pure after quantifying each individual component (oncocytic and clear) since pure and mixed oncocytic tumors do not seem to share similar clinical outcome.[[4]] The tumor was composed of entirely oncocytic cells in the present case. Adrenocortical tumors are usually solitary lesions and their vast majority occur in adults without sex predilection.[[3]] Bisceglia et al. have proposed categories for OAN as pure oncocytic tumor, if a tumor is exclusively or almost entirely composed (greater than 90%) of oncocytic cells, mixed oncocytic tumor, when a clear cell component is also present (ranging from 10 to 50%), and ordinary adrenocortical tumor with focal oncocytic changes, if the oncocytic component is not a predominant one (less than 50% of the tumor mass). [Extracted from the article]