TWO STEP SYNTHESIS OF INDAZOLE DERIVATIVES AND THEIR ANTI-CANCER EVALUATION.

Herein we described the synthesis of indazole derivatives through C-N cyclization and evaluated for their anticancer activities against three human cancer cell lines such as HeLa, MCF-7, and SKOV3 using MTT assay. The synthesized indazole hybrids are characterized based on 1H NMR, 13C NMR spectral data, and elemental analysis. The results indicated that the most potent molecule in this series is compound 3b against MCF-7, compound 3h against HeLa, and compound 3d against SKOV3, which showed the highest activity with an IC50 value of 32.92 μg/ml, 12.08 μg/ml, and 29.06 µg/ml respectively. [ABSTRACT FROM AUTHOR]