Different mechanisms in periventricular and deep white matter hyperintensities in old subjects.

Objective: Althoughmultiple pieces of evidence have suggested that there are dierentmechanisms in periventricular whitematter hyperintensities (PWMHs) and deep white matter hyperintensities (DWMHs), the exact mechanism remains uncertain. Methods: We reviewed clinical and imaging data of old participants from a local She Ethnic group. We assessed the cerebral blood flow of white matter (WM-CBF) on arterial spin-labeling, deep medullary veins (DMVs) visual score on susceptibility-weighted imaging, and index for diusion tensor image analysis along the perivascular space (ALPS index), indicating glymphatic function on diusion tensor imaging. Furthermore, we investigated their relationships with volumes of PWMHs and DWMHs. Results: A total of 152 subjects were included, with an average age of 63 ± 8 years old. We found that higher age and history of hypertension were independently related to higher volumes of both PWMHs and DWMHs (all p < 0.05). Lower ALPS index was independently associated with higher PWMHs volumes (b = 0.305, p < 0.001), and this relationship was accounted for by the indirect pathway via DMVs score (b = 0.176, p = 0.017). Both lower ALPS index and WM-CBF were independent risk factors for higher DWMHs volumes (b = -0.146, p = 0.041; b = -0.147, p = 0.036). Conclusions: Our study indicated that there were dierent mechanisms in PWMHs and DWMHs. PWMHs were mainly attributed to the damage of veins due to the dysfunction of the glymphatic pathway, while DWMHs could be aected by both ischemia-hypoperfusion and dysfunction of the glymphatic pathway. Advances in knowledge: The relationship between glymphatic dysfunction and PWMHs might be accounted for by the indirect pathway via venous abnormalities, a glymphatic dysfunction, and lower CBF in white matter were independent risk factors for DWMHs. [ABSTRACT FROM AUTHOR]