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Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence in Massachusetts Estimated from Newborn Screening Specimens.

Authors :
Ma, Kevin C
Hale, Jaime E
Grad, Yonatan H
Alter, Galit
Luzuriaga, Katherine
Eaton, Roger B
Fischinger, Stephanie
Kaur, Devinder
Brody, Robin
Siddiqui, Sameed M
Leach, Dylan
Brown, Catherine M
Klevens, R Monina
Madoff, Lawrence
Comeau, Anne Marie
Source :
Clinical Infectious Diseases; Jul2022, Vol. 75 Issue 1, pe105-e113, 9p
Publication Year :
2022

Abstract

Background Estimating the cumulative incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for setting public health policies. We leveraged deidentified Massachusetts newborn screening specimens as an accessible, retrospective source of maternal antibodies for estimating statewide seroprevalence in a nontest-seeking population. Methods We analyzed 72 117 newborn specimens collected from November 2019 through December 2020, representing 337 towns and cities across Massachusetts. Seroprevalence was estimated for the Massachusetts population after correcting for imperfect test specificity and nonrepresentative sampling using Bayesian multilevel regression and poststratification. Results Statewide seroprevalence was estimated to be 0.03% (90% credible interval [CI], 0.00–0.11) in November 2019 and rose to 1.47% (90% CI: 1.00–2.13) by May 2020, following sustained SARS-CoV-2 transmission in the spring. Seroprevalence plateaued from May onward, reaching 2.15% (90% CI: 1.56–2.98) in December 2020. Seroprevalence varied substantially by community and was particularly associated with community percent non-Hispanic Black (β = .024; 90% CI: 0.004–0.044); i.e. a 10% increase in community percent non-Hispanic Black was associated with 27% higher odds of seropositivity. Seroprevalence estimates had good concordance with reported case counts and wastewater surveillance for most of 2020, prior to the resurgence of transmission in winter. Conclusions Cumulative incidence of SARS-CoV-2 protective antibody in Massachusetts was low as of December 2020, indicating that a substantial fraction of the population was still susceptible. Maternal seroprevalence data from newborn screening can inform longitudinal trends and identify cities and towns at highest risk, particularly in settings where widespread diagnostic testing is unavailable. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10584838
Volume :
75
Issue :
1
Database :
Complementary Index
Journal :
Clinical Infectious Diseases
Publication Type :
Academic Journal
Accession number :
158756527
Full Text :
https://doi.org/10.1093/cid/ciac158