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Effect of chitooligosaccharides with a specific degree of polymerization on multiple targets in T2DM mice.
- Source :
- Bioresources & Bioprocessing; 9/5/2022, Vol. 9 Issue 1, p1-20, 20p
- Publication Year :
- 2022
-
Abstract
- Chitooligosaccharides (COS) are found naturally in the ocean and present a variety of physiological activities, of which hypoglycemic action has attracted considerable research attention. This study aimed to assess the therapeutic effect of COS on mice suffering from type 2 diabetes mellitus (T2DM). COS effectively reduced blood glucose and blood lipid levels and improved glucose tolerance. Furthermore, COS revealed strong inhibitory activity against α-glucosidase, reducing postprandial blood glucose levels. Molecular docking data showed that COS might interact with surrounding amino acids to form a complex and decrease α-glucosidase activity. Additionally, COS enhanced insulin signal transduction and glycogen synthesis while restricting gluconeogenesis in the liver and muscles, reducing insulin resistance (IR) as a result. Moreover, COS effectively protected and restored islet cell function to increase insulin secretion. These results indicated that COS exhibited a significant hypoglycemic effect with multi-target participation. Therefore, COS may serve as a new preventive or therapeutic drug for diabetes to alleviate metabolic syndrome. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21974365
- Volume :
- 9
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Bioresources & Bioprocessing
- Publication Type :
- Academic Journal
- Accession number :
- 158884986
- Full Text :
- https://doi.org/10.1186/s40643-022-00579-3