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Recovery from AA amyloidosis-cardiomyopathy complexed with unicentric Castleman disease.

Authors :
Kanako Imamura
Sunao Kojima
Takahisa Imamura
Kenichi Tsujita
Source :
BMJ Case Reports; Aug2022, Vol. 15 Issue 8, p1-4, 4p
Publication Year :
2022

Abstract

We report a case of cardiac amyloid A (AA) amyloidosis due to unicentric Castleman disease (UCD) in a patient whose cardiac function was restored 15 years after surgical resection of the mesenteric lymph node lesion. A man in his 40s had recurrent palpitations and fainting spells. ECG revealed torsades de pointes. Increased C-reactive protein, interleukin-6 and serum AA levels, and marked concentric thickening of the left ventricular (LV) wall with diastolic restrictive filling pattern were observed. Duodenal biopsy revealed AA amyloid deposits. He had a mesenteric tumour, comprising many plasma cells. He was diagnosed with plasma cell-type UCD associated with secondary AA amyloidosis. Creactive protein, interleukin-6 and serum AA levels were normalised 2 months postresection. Episodes of lethal ventricular arrhythmias decreased. LV wall thickness was gradually reduced. Approximately 15 years postresection, the LV wall thickness nearly normalised and ventricular arrhythmias disappeared. Better outcomes are expected following surgical tumour resection. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1757790X
Volume :
15
Issue :
8
Database :
Complementary Index
Journal :
BMJ Case Reports
Publication Type :
Academic Journal
Accession number :
158894309
Full Text :
https://doi.org/10.1136/bcr-2022-250338