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Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Reduces AChR Clustering by Dephosphorylating MuSK.
- Source :
- Disease Markers; 9/5/2022, p1-10, 10p
- Publication Year :
- 2022
-
Abstract
- Neuromuscular junction (NMJ) formation and maintenance depend on the proper localization and concentration of various molecules at synaptic contact sites. Acetylcholine receptor (AChR) clustering on the postsynaptic membrane is a cardinal event in NMJ formation. Muscle-specific tyrosine kinase (MuSK), which functions depending on its phosphorylation, plays an essential role in AChR clustering. In the present study, we used plasmid-based biochemical screening and determined that protein tyrosine phosphatase receptor type R (PTPRR) is responsible for dephosphorylating MuSK on tyrosine residue 754. Furthermore, we showed that PTPRR significantly reduced MuSK-dependent AChR clustering in C2C12 myotubes. Collectively, these data illustrate a negative regulation function of PTPRR in AChR clustering. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02780240
- Database :
- Complementary Index
- Journal :
- Disease Markers
- Publication Type :
- Academic Journal
- Accession number :
- 158909471
- Full Text :
- https://doi.org/10.1155/2022/5160624