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Association between Circulating Levels of 25-Hydroxyvitamin D 3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes.
- Source :
- Nutrients; Sep2022, Vol. 14 Issue 17, p3484, 11p
- Publication Year :
- 2022
-
Abstract
- Background: Matrix metalloproteinase-10 (MMP-10) levels increase progressively starting from early diabetic kidney disease (DKD) stages. Vitamin D<subscript>3</subscript> (vitD<subscript>3</subscript>) deficit is associated with a higher risk of diabetic microangiopathy. Reduced MMP-10 expression has been observed after exposure to vitD<subscript>3</subscript>. Aim: to assess how vitD<subscript>3</subscript> status is related to MMP-10 levels in patients with Type 2 diabetes (T2D). Methods: 256 patients with T2D were included in this cross-sectional study. Demographic, clinical and serum MMP-10 and 25-hydroxyvitamin D<subscript>3</subscript> (25(OH)D<subscript>3</subscript>) levels were collected from each patient. The association between MMP-10 and (25(OH)D<subscript>3</subscript>) levels was assessed using a correlation analysis and fitting a multivariate linear regression model. Results: Serum MMP-10 levels were inversely correlated with circulating 25(OH)D<subscript>3</subscript> (rho = −0.25; p < 0.001). In the subgroup analysis this correlation was significant in patients with DKD (rho = −0.28; p = 0.001) and in subjects with vitD<subscript>3</subscript> deficit (rho = −0.24; p = 0.005). In the regression model adjusted for kidney function, body adiposity, smoking and vitD supplementation MMP-10 levels were 68.7 pg/mL lower in patients with 25(OH)D<subscript>3</subscript> > 20 ng/mL, with respect to ≤20 ng/mL (p = 0.006). Conclusions: vitD<subscript>3</subscript> repletion status is an independent predictor of MMP-10 levels in T2D patients. Perhaps, high 25(OH)D<subscript>3</subscript> values should be targeted in these patients in order to prevent vascular complications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 14
- Issue :
- 17
- Database :
- Complementary Index
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 159035982
- Full Text :
- https://doi.org/10.3390/nu14173484