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Carboxymethyl cellulose-coated HKUST-1 for baclofen drug delivery in vitro.
- Source :
- Chemical Papers; Oct2022, Vol. 76 Issue 10, p6557-6566, 10p
- Publication Year :
- 2022
-
Abstract
- Metal–organic frameworks are the new type of crystalline porous materials with specific properties such as appropriate catalytic activity, accessible surface area, tunable pore structure, as well as stable chemical and thermal properties. In this study, solvothermal preparation of a copper-metal organic framework (HKUST; Hong Kong University of Science and Technology) was used to load baclofen as a model drug. Baclofen-HKUST-1 was employed to increase the drug release controllability of bio-polymeric carboxymethyl cellulose (CMC) hydrogel under the gastrointestinal tract (GIT). Results from in vitro drug delivery and kinetic assessments revealed that CMC/baclofen-HKUST-1 bio-nanocomposite could better act against stomach pH; it also increased the releasing homogeneity and drug delivery under GIT conditions. Also, MTT assay demonstrated there was considerable cytotoxicity against human colon cells associated with CMC/baclofen-HKUST-1 bio-nanocomposite. According to the findings of CMC/baclofen-HKUST-1 bio-nanocomposite assessments, the mentioned component could be applied to drug administration. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03666352
- Volume :
- 76
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Chemical Papers
- Publication Type :
- Academic Journal
- Accession number :
- 159141536
- Full Text :
- https://doi.org/10.1007/s11696-022-02348-0