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Dietary Supplementation of 25-Hydroxyvitamin D 3 Improves Growth Performance, Antioxidant Capacity and Immune Function in Weaned Piglets.
- Source :
- Antioxidants; Sep2022, Vol. 11 Issue 9, p1750-1750, 17p
- Publication Year :
- 2022
-
Abstract
- This study was conducted to evaluate the effects of 25-hydroxyvitamin D<subscript>3</subscript> (25(OH)VD<subscript>3</subscript>) and Vitamin D<subscript>3</subscript> (VD<subscript>3</subscript>) supplemented in the diet of weaned piglets on their growth performance, bone quality, intestinal integrity, immune function and antioxidant capacity. A total of 192 weaned piglets were allocated into four groups and they were fed a control diet containing 2000 IU VD<subscript>3</subscript> (negative control, NC), NC + 100 ppm colistin sulfate (positive control, PC), NC + 2000 IU VD<subscript>3</subscript> (VD<subscript>3</subscript>) and NC + 2000 IU 25(OH)VD<subscript>3</subscript> (25(OH)VD<subscript>3</subscript>)<subscript>.</subscript> The results showed that 25(OH)VD<subscript>3</subscript> improved the growth performance, bone quality and antioxidase activity of piglets compared with the other groups. Meanwhile, 25(OH)VD<subscript>3</subscript> up-regulated ileal mRNA expressions of tight junction proteins and host defense peptides. The VD<subscript>3</subscript> group had an increased intestinal sIgA content and mRNA expression of pBD-1 compared with the NC group. Both groups of VD<subscript>3</subscript> and 25(OH)VD<subscript>3</subscript> altered the microbial β-diversity compared with the NC group, and 25(OH)VD<subscript>3</subscript> increased ileal concentrations of acetate and butyrate. In conclusion, our findings indicated that a regular dosage of 2000 IU VD<subscript>3</subscript> in the weaned piglets' diet did not achieve optimal antioxidant capacity and immune function. 25(OH)VD<subscript>3</subscript> had better growth performance than VD<subscript>3</subscript> at the same inclusion level, which is associated with the improved intestinal integrity and antioxidant capacity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20763921
- Volume :
- 11
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Antioxidants
- Publication Type :
- Academic Journal
- Accession number :
- 159272254
- Full Text :
- https://doi.org/10.3390/antiox11091750