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A split‐face, blind, randomized placebo‐controlled clinical trial investigating the efficacy and safety of hyaluronic acid filler for the correction of atrophic facial scars.
- Source :
- Journal of Cosmetic Dermatology; Sep2022, Vol. 21 Issue 9, p3768-3778, 11p
- Publication Year :
- 2022
-
Abstract
- Background: Hyaluronic acid fillers have been studied extensively for facial wrinkles; however, their efficacy for atrophic facial scars has yet to be analyzed in a prospective placebo‐controlled study. Objective: To analyze the efficacy and safety of a hyaluronic acid filler for atrophic facial scars. Methods & Materials: Fifteen subjects were randomized to receive up to 1 ml of VYC‐17.5 L on one cheek and up to 1 ml of saline on the other side, with an optional touch‐up treatment. Subjects were graded by a live blind evaluator using the Quantitative Global Scarring Grading System (QGSGS) (J Cosmet Dermatol. 2006;5:48), the Global Aesthetic Improvement Scale (GAIS), and Canfield photo‐analysis. Results: According to the blind evaluator, there was a significant reduction 90 days after the last treatment on the QGSGS for VYC‐17.5L compared with saline (−6.6 VYC‐17.5L vs −1.7 saline [t(28) = −4.3196, p = 0.008]). There was a smaller, but still significant reduction on the QGSGS for saline alone (10.4 to 8.6 [t(14) = −3.453, p = 0.004]). In addition, 93% (13/14) of subjects chose VYC‐17.5L over saline treatment and reported an improvement on the GAIS. There were no serious side effects and all minor side effects resolved by Day 30. Conclusion: VYC‐17.5L achieved significant improvements in rolling atrophic scars as compared to saline, though saline also had modest improvements. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYALURONIC acid
SCARS
REJUVENATION
CLINICAL trials
Subjects
Details
- Language :
- English
- ISSN :
- 14732130
- Volume :
- 21
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Cosmetic Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 159327275
- Full Text :
- https://doi.org/10.1111/jocd.15153